Disease: Hypercholesterolemia
Source: ALL
Gene Uniprot Gene Full Name Protein Class pLI DSI v DPI v
ZPR1 O75312 ZPR1 zinc finger 8.9E-09 0.674 0.462
VLDLR P98155 very low density lipoprotein receptor 2.0E-11 0.558 0.692
UGT1A1 P22309 UDP glucuronosyltransferase family 1 member A1 3.3E-06 0.464 0.769
SORT1 Q99523 sortilin 1 Transporter 1.00 0.573 0.615
SH2B3 Q9UQQ2 SH2B adaptor protein 3 1.0E-04 0.527 0.692
PPARG P37231 peroxisome proliferator activated receptor gamma Nuclear receptor 2.9E-02 0.358 0.885
PPARA Q07869 peroxisome proliferator activated receptor alpha Nuclear receptor 3.0E-02 0.432 0.885
PLA2G15 Q8NCC3 phospholipase A2 group XV Enzyme 0.38 0.520 0.769
PCSK9 Q8NBP7 proprotein convertase subtilisin/kexin type 9 Enzyme 2.7E-17 0.482 0.808
NR1I2 O75469 nuclear receptor subfamily 1 group I member 2 Nuclear receptor 7.3E-09 0.418 0.846
NPC1L1 Q9UHC9 NPC1 like intracellular cholesterol transporter 1 Transporter 2.3E-20 0.656 0.423
LRP2 P98164 LDL receptor related protein 2 1.00 0.491 0.846
LPA P08519 lipoprotein(a) Enzyme 6.6E-89 0.444 0.769
LIPC P11150 lipase C, hepatic type Enzyme 3.3E-07 0.585 0.654
LEPR P48357 leptin receptor Signaling 0.99 0.433 0.808
LDLR P01130 low density lipoprotein receptor 9.8E-24 0.449 0.885
LCAT P04180 lecithin-cholesterol acyltransferase Enzyme 8.1E-02 0.588 0.654
KDR P35968 kinase insert domain receptor Kinase 1.00 0.378 0.885
IKBKB O14920 inhibitor of nuclear factor kappa B kinase subunit beta Kinase 0.99 0.506 0.846
ICAM1 P05362 intercellular adhesion molecule 1 3.5E-02 0.364 0.962
HNF1A P20823 HNF1 homeobox A Nucleic acid binding 0.96 0.478 0.846
HMGCR P04035 3-hydroxy-3-methylglutaryl-CoA reductase 1.00 0.529 0.692
GSR P00390 glutathione-disulfide reductase Enzyme 1.3E-06 0.494 0.846
F3 P13726 coagulation factor III, tissue factor Receptor 1.9E-02 0.415 0.846
ESR1 P03372 estrogen receptor 1 Nuclear receptor 1.00 0.324 0.962